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ÓLEO DE CANABIDIOL: o que a ciência (realmente) diz sobre 8 usos "populares"?

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ATENÇÃO: Esse vídeo foi feito em cima de uma pesquisa pessoal pelas bases de busca PubMed, Web of Science, Science Direct e SciELO.org. É preciso que fique claro que você, ser humano com livre arbítrio, pode fazer o uso de qualquer coisa do jeito que bem entender, PORÉM nós profissionais de saúde só devemos indicar ou recomendar qualquer coisa com, pelo menos, um mínimo aceitável de evidência científica. Não quer dizer que daqui há um tempo um uso sem evidência hoje ganhe bastante respaldo científico e passe a ser indicado amanhã, coisas novas saem a todo o tempo.

Minutagem:
1:58 O que é o cbd?
3:18 Epilepsia
4:28 Dores Crônicas
5:14 Ansiedae e Depressão
07:28 Antibiótico
08:19 Inflamação/Stress Oxidativo
08:57 Emagrece
09:35 Câncer
11:15 Pele/Skincare

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O número de caracteres da descrição não permite que eu cite todas as referências usadas, então colocarei as principais (principalmente estudos clínicos) por uso, o nome do artigo e doi para que vocês localizem mais facilmente.

Epilepsia
“Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy.”
doi: 10.1007/s40265-019-01171-4
“Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome.” doi:10.1056/nejmoa1714631.
“Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.” doi:10.1056/nejmoa1611618.
“Evidence for Cannabis and Cannabinoids for Epilepsy: a Systematic Review of Controlled and Observational Evidence.” doi:10.1136/jnnp-2017-317168.
“Cannabidiol in Patients with Seizures Associated with Lennox-Gastaut Syndrome (GWPCARE4): a Randomised, Double-Blind, Placebo-Controlled Phase 3 Trial.” doi:10.1016/s0140-6736(18)30136-3.

Ansiedade/Depressão/Desordens Psiquiátricas
“Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients.” doi:10.1038/npp.2011.6.
“Cannabidiol as a Potential Treatment for Anxiety Disorders.” doi:10.1007/s13311-015-0387-1
“Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders.” doi:10.3389/fphar.2016.00454.
“Is There a Role for Cannabidiol in Psychiatry?” The World Journal of Biological Psychiatry, 2017, pp. 1–16., doi:10.1080/15622975.2017.1285049.
“Evidences for the Anti-Panic Actions of Cannabidiol.” doi:10.2174/1570159×14666160509123955.
“Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life.” doi:10.3389/fphar.2017.00259.

Dor Crônica
“Preliminary Assessment of the Efficacy, Tolerability and Safety of a Cannabis-Based Medicine (Sativex) in the Treatment of Pain Caused by Rheumatoid Arthritis.” doi:10.1093/rheumatology/kei183.
“Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain.” doi:10.1016/j.jpainsymman.2009.06.008.
“Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain.” doi:10.1016/j.jpainsymman.2017.09.001.
“Cannabis-Based Medicines for Chronic Neuropathic Pain in Adults.” doi:10.1002/14651858.cd012182.pub2.
“A Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study of THC/CBD Spray in Peripheral Neuropathic Pain Treatment.” doi:10.1002/j.1532-2149.2013.00445.x.

Câncer
“Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer.” doi: 10.3390/ijms20235905
“Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.” doi:10.6004/jnccn.2016.0094.
“Sativex Oromucosal Spray as Adjunctive Therapy in Advanced Cancer Patients with Chronic Pain Unalleviated by Optimized Opioid Therapy: Two Double-Blind, Randomized, Placebo-Controlled Phase 3 Studies.” doi:10.1177/2049463717710042.
“Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma.” doi:10.1124/jpet.106.105247.
“Cannabidiol as Potential Anticancer Drug.” doi:10.1111/j.1365-2125.2012.04298.x.

Inflamação/Stress oxidativo
“Cannabinoids as Novel Anti-Inflammatory Drugs” doi:10.4155/fmc.09.93.
“Cannabidiol Exerts Sebostatic and Antiinflammatory Effects on Human Sebocytes.” doi:10.1172/jci64628.

Efeitos na Pele
“Epigenetic Control of Skin Differentiation Genes by Phytocannabinoids.” doi:10.1111/bph.12309.
“Cannabinoids Inhibit Human Keratinocyte Proliferation through a Non-CB1/CB2 Mechanism and Have a Potential Therapeutic Value in the Treatment of Psoriasis.” doi:10.1016/j.jdermsci.2006.10.009.

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