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CBD, Capsaicin or SSRI antidepressants to Treat Cannabis Hyperemesis Syndrome? || NeuroBeer


#CBD #CHS #cannabis #capsaicin #SSRI
In this clip we discuss how cannabis causes nausea, the potential benefits of CBD vs capsaicin vs SSRIs in treating Cannabinoid Hyperemesis Syndrome, and ponder the potential biology, such as similar overlapping 5-HT mechanisms involved in mediating the benefits that each of these drugs have been suggested to have. We also extrapolate findings from a recent August 2020 publication assessing the acute effects of CBD on regional cerebral blood flow in the human brain – the article suggests CBD selectively boosts blood flow to the hippocampus for as yet unknown reasons.

Is it that CBD specifically increases blood flow only to the hippocampus? Or is it that CBD accumulates in hippocampal tissue due to heightened concentrations of receptor targets, leading to enhanced blood flow? Is it an indirect effect via a different brain region or possibly not a neural-mediated effect at all? Check out our commentary where we also link these results with related results published in early 2019 demonstrating that CBD can reverse the long-term negative impacts of high-THC cannabis exposure on hippocampal volume deficits. We also briefly discuss David Blaine in the context of hippocampus hypoxia: https://youtu.be/sE3dCr-QllQ

From NeuroBeer #13: https://youtu.be/2rIiUwG03VY

Peer-reviewed manuscripts discussed: https://journals.sagepub.com/doi/10.1177/0269881120936419 – The effects of acute cannabidiol on cerebral blood flow and its relationship to memory: An arterial spin labelling magnetic resonance imaging study
& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908414/ – Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users

Additional resources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576702/
& https://www.analyticalcannabis.com/articles/understanding-cannabis-hyperemesis-syndrome-311560
& https://www.projectcbd.org/medicine/cannabis-hyperemesis-syndrome

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Produced by Roger Hudson, PhDc,
Dr. Mina Nashed, PhD,
Dr. Stephen Daniels, PhD,
Dr. Paul Sheppard, PhD,
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Marieka Devuono, PhDc,
Sarah Pravato, BSc,
Nicole Buchner, BSc,
Thomas Lapointe, PhDc
& Dr. Daniel Palmer, PhD
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